overeed mutant optineurin e50k induces retinal

A glaucoma-associated mutant of optineurin

RESULTS The E50K mutant of optineurin selectively induced the death of retinal ganglion cells but not of the other cell lines tested. Although the eion of optineurin and E50K mutant suppressed cell death induced by tumor necrosis factor-alpha in HeLa cells, they potentiated this cell death in retinal

(PDF) A Glaucoma-Associated Mutant of Optineurin

E50K mutant of optineurin selectively induces the death of RGCs. (A) Effect of eion of various mutants of optineurin on the induction of cell death in RGC-5 cells. 661W is a retinal ganglion precursor-like cell line in Dec 04, 2017 · However, in a motor neuron cell line, NSC34, E478G mutant of OPTN but not E50K and M98K induced cell death. We conclude that 661W is a retinal ganglion precursor-like

A Glaucoma-Associated Mutant of Optineurin Selectively

A Glaucoma-Associated Mutant of Optineurin Selectively Induces Death of Retinal Ganglion Cells Which Is Inhibited by Antioxidants Chalasani, Madhavi Latha, Radha, Vegesna, Gupta, Vijay, Agarwal, Neeraj, Balasubramanian, Dorairajan, Swarup, Ghanshyam A glaucoma-associated mutant of optineurin selectively (2007) Chalasani et al. Investigative Ophthalmology and Visual Science. PURPOSE. Mutations in the coding region of the OPTN gene are associated with certain glaucomas. Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a sev

A glaucoma-associated mutant of optineurin selectively

Mutations in the coding region of the OPTN gene are associated with certain glaucomas. Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a severe phenotype. This study explores some functional features of optineurin and its mutants. Plasmids eing normal or wild-type (WT) and E50K, R545Q, H26D, and H486R mutant A glaucoma-associated mutant of optineurin selectively RESULTS:The E50K mutant of optineurin selectively induced the death of retinal ganglion cells but not of the other cell lines tested. Although the eion of optineurin and E50K mutant suppressed cell death induced by tumor necrosis factor-alpha in HeLa cells, they potentiated this cell death in retinal

Citation - PubAg

Overeed mutant optineurin(E50K) induces retinal ganglion cells apoptosis via the mitochondrial pathway MLA Meng, Qingfeng, et al. "Overeed Mutant Optineurin(e50k) Induces Retinal Ganglion Cells Apoptosis Via the Mitochondrial Pathway." Molecular biology reports, v. 39,.5 pp. 5867-5873. doi:10.1007/s11033-011-1397-7 APA CiteSeerX E50K-OPTN-Induced Retinal Cell Death Involves CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda):The protein optineurin coded by OPTN gene is involved in several functions including regulation of endocytic trafficking, autophagy and signal transduction. Certain missense mutations in the gene OPTN cause normal tension glaucoma. A glaucoma-causing mutant of optineurin, E50K, induces death selectively in retinal cells.

E50K-OPTN-Induced Retinal Cell Death Involves the Rab

Apr 21, 2014 · E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy. Item Preview E50K-OPTN-induced retinal cell death involves the Rab A glaucoma-causing mutant of optineurin, E50K, induces death selectively in retinal cells. This mutant induces defective endocytic recycling of transferrin receptor by causing inactivation of Rab8 mediated by the GTPase-activating protein, TBC1D17. Here, we have explored the mechanism of E50K-induced

E50K-OPTN-induced retinal cell death involves the Rab

The protein optineurin coded by OPTN gene is involved in several functions including regulation of endocytic trafficking, autophagy and signal transduction. Certain missense mutations in the gene OPTN cause normal tension glaucoma. A glaucoma-causing mutant of optineurin, E50K, induces death selectively in retinal cells. This mutant induces defective endocytic recycling of transferrin receptor Eion profiling of microRNAs in optineurin (E50K An E50K substitution in the transcription factor optineurin (OPTN) induces primary open-angle glaucoma (POAG). To explore the potential role of microRNAs (miRNAs) in E50K OPTNinduced POAG, miRNA eion profiling was performed on retinal samples from OPTN (E50K) trans-genic and wild-type mice. The retinas were collected from

Functional analysis of optineurin and some of its disease

Apr 09, 2015 · The possibility of functional defects in optineurin mutants, which are relevant for glaucoma, was examined by eing various mutants of optineurin in the retinal cell line, RGC-5, and it was observed that two of these mutants, namely, E50K and M98K, induced significantly more cell death than wild-type OPTN 42, 45. Sparrho Effects of abnormal optineurin eion on the Sep 09, 2015 · A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants. Research paper by Madhavi Latha ML Chalasani, Vegesna V Radha, Vijay V Gupta, Neeraj N Agarwal, Dorairajan D Balasubramanian, Ghanshyam G Swarup. Indexed on:29 Mar '07 Published on:29 Mar '07 in Investigative ophthalmology & visual

Transgenic mice with overeion of mutated human

Jun 17, 2011 · Mutated human OPTN(E50K) selectively induced the death of rat retinal ganglion cells (RGC-5) but not of other 3 cell lines tested . Neither the mutants of optineurin tested (H26D, R545Q, H486R) nor normal optineurin induced cell death in RGC-5 . overeed mutant optineurin e50k induces retinal overeed mutant optineurin e50k induces retinal. Overeed mutant optineurin(E50K) induces retinal (steel) The mutant Optineurin(E50K) induced the death of retinal ganglion cells by generation of reactive oxygen species accompanied disruption of mitochondrial transmembrane potential, down-regulation of bcl-2, and up-regulation of bax, which led to the release of cytochrome C from the

Overeed mutant optineurin(E50K) induces retinal

Mutations in the coding region of the OPTN gene are associated with certain glaucomas. Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a severe phenotype. Plasmids eing wild-type Optineurin (WT) and mutant Optineurin(E50K) were transfected into RGC-5 and monitored by immunofluorescence staining and western blotting.